منابع مشابه
Imidazole catalysis. II. Acyl transfer and the reactions of acetyl imidazole with water and oxygen anions.
Catalysis of p-nitrophenyl acetate hydrolysis by imidazole and its derivatives has been described in a number of investigations, of which the most extensive are those by Bruice and Schmir and by Bender and Turnquest (2-9). Imidaaole catalysis of the transfer of activated acyl groups from acyl phosphates to a number of acceptor molecules, which is a model for carboxylactivating enzymes and trans...
متن کاملImidazole Aldoximes Effective in Assisting Butyrylcholinesterase Catalysis of Organophosphate Detoxification
Intoxication by organophosphate (OP) nerve agents and pesticides should be addressed by efficient, quickly deployable countermeasures such as antidotes reactivating acetylcholinesterase or scavenging the parent OP. We present here synthesis and initial in vitro characterization of 14 imidazole aldoximes and their structural refinement into three efficient reactivators of human butyrylcholineste...
متن کاملControl of Modes of Intramolecular Imidazole Catalysis of Ester Hydrolysis by Steric and Electronic Effects
The various mechanisms by which a neighboring imidazolyl nitrogen base (both neutral and anionic) or the conjugate acid imidazolium cation may participate in the hydrolysis of an acetyl ester of a weakly basic or strongly basic phenol have been evaluated (pH 0-13). For this purpose 0-acetyl esters of 2 4 2 ’ and 4‘-hydroxypheny1)imidazoles were prepared (Ia, b, 11, IIIa, b, and IV). Lyate speci...
متن کاملIonic Liquid Solvation versus Catalysis: Computational Insight from a Multisubstituted Imidazole Synthesis in [Et2NH2][HSO4]
The mechanisms of a tetrasubstituted imidazole [2-(2,4,5-triphenyl-1 H-imidazol-1-yl)ethan-1-ol] synthesis from benzil, benzaldehyde, ammonium acetate, and ethanolamine in [Et2NH2][HSO4] ionic liquid (IL) are studied computationally. The effects of the presence of the cationic and anionic components of the IL on transition states and intermediate structures, acting as a solvent versus as a cata...
متن کاملImidazole-based potential Bi- and tridentate nitrogen ligands: synthesis, characterization and application in asymmetric catalysis.
Twelve new imidazole-based potential bi- and tridentate ligands were synthesized and characterized. Whereas in the first series the alpha-amino acid and imidazole moieties were linked by an amino bond, in the second series the tridentate ligands, containing two imidazole groups, were separated by an amide bond. The first series was obtained by the reductive amination of 2-phenylimidazole-4-carb...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1959
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)98173-1